Pregabalin Induced Maculopapular Eruption in an Elderly Male

Abstract

Abstract: Pregabalin is used in the treatment of neuropathic pain of various etiologies and as adjuvant in epilepsy. Blockade of the α2δ subunit of L and N type Ca-channels is its main mechanism of neurotropic action. Compared to other antiepileptics like phenytoin, valproate and lamotrigine, and other neuropathic pain medications such as amitriptyline and duloxetine, pregabalin has a relatively favorable safety profile and hence is a drug of choice for many geriatricians. Here we describe a case of maculopapular rash induced by pregabalin in an elderly man which resolved with withdrawal of the offending drug and conservative management. We have also conducted a literature review of similar cases and highlight the clinical patterns and management strategies for pregabalin induced skin rashes.