Mini Review on Polymer-based Nano Enable System for Targeted Delivery of Chalcone Derivatives against Cancerous Tissues: An Effective Treatment Approach

Abstract

Abstract: Nanotechnology augmentation have enabled the creation of innovative colloidal preparations that can modify the pharmacological characteristics of medications. Numerous effective applications in the treatment of cancer have been made possible by the distinctive physicochemical and technological characteristics of therapies based on nanomaterials. To facilitate and maximize the interaction between cells and tissues, it is necessary to examine and modify the size, shape, charge, and patterning of nanoscale therapeutic molecules. The flavonoids chalcones and their natural scaffolds provide a variety of biological effects crucial for creating medicines. Plant-based anticancer medicines represent a promising scientific and business opportunity that should be investigated. By using traditional Chinese medicine (TCM) therapies, diseases can be avoided, and healthcare can be enhanced. Traditional Chinese medicine is safe, straightforward, and reasonably priced. There are numerous treatments for chronic, geriatric, and incurable diseases. Heterocyclic equivalents of chalcones have a variety of biological properties. One of them is its anti-cancer properties, and as a result Chalcones have drawn a huge interest in the study of malignancy. Licorice is an essential primary ingredient in many traditional folk medicines, including Chinese and Mongolian medicine. Research on chalcone scaffolds with strong growth-inhibitory activity in tumor cell lines was influenced by the rising interest in this medicinal molecule, and numerous papers on these scaffolds are now accessible. It is necessary to do a thorough examination before chalcone congeners can be developed as a prodrug or primary chemical to treat cancer. To create a focused and efficient drug delivery system for cancer treatment, we shall discuss chalcone derivatives and their nano-enabled drug delivery systems in this article. It has been discussed how polymeric nanoparticles might effectively localize in particular tumor tissues and act as drug delivery vehicles for anticancer drugs due to their physicochemical characteristics. A promising strategy to increase the effectiveness of various tumor treatments is the nanoencapsulation of anticancer active substances in polymeric systems.