Antitumor Effects of Curcumin on Cervical Cancer with the Focus on Molecular Mechanisms: An Exegesis-Reference-Cited by-同舟云学术

Antitumor Effects of Curcumin on Cervical Cancer with the Focus on Molecular Mechanisms: An Exegesis

Published:2023-11 Issue:42 Volume:29 Page:3385-3399
ISSN:1381-6128
Container-title:Current Pharmaceutical Design
language:en
Short-container-title:CPD

Author:

Govahi Ali¹,Zahmatkesh Neda²,Pourbagherian Omid³,Khas Neda Maleki²,Salamzadeh Tala⁴,Mehr Hasti Moshtagh⁵,Babaei Esmaeil⁶,Hajivalili Mahsa⁷

Affiliation:

1. Department of Medical Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2. Department of Genetic, Faculty of Medical and Sciences, Islamic Azad University, Zanjan Branch, Zanjan, Iran

3. Department of Biochemistry and Nutrition, Faulty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

4. School of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran

5. Department of Plant Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran

6. Department of Animal Biology, School of Natural Sciences, University of Tabriz, Tabriz, Iran

7. Department of Immunology, Behbahan Faculty of Medical Sciences, Behbahan, Iran

Abstract

Abstract: Cervical cancer is one of the most prevalent malignancies among females and is correlated with a significant fatality rate. Chemotherapy is the most common treatment for cervical cancer; however, it has a low success rate due to significant side effects and the incidence of chemo-resistance. Curcumin, a polyphenolic natural compound derived from turmeric, acts as an antioxidant by diffusing across cell membranes into the endoplasmic reticulum, mitochondria, and nucleus, where it performs its effects. As a result, it's been promoted as a chemo-preventive, anti-metastatic, and anti-angiogenic agent. As a consequence, the main goal of the present review was to gather research information that looked at the link between curcumin and its derivatives against cervical cancer.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

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