Affiliation:
1. Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey
Abstract
Abstract:
A new series of bisthiosemicarbazide and bistriazole molecules bridged quinazolinedione
was synthesized and characterized by FT-IR, 1
H and 13C-NMR spectral data. Antiurease activities
of all new compounds were tested according to the phenol-hypochlorite method by Weatherburn. All
compounds have effective urease inhibition activities compared to the standard inhibitor thiourea and
previously synthesized quinazolinones as potential inhibitors. Bistriazoles containing quinazolinedione
have the best inhibition results. 1,3-Bis[(4-ethyl-5-mercapto-4H-1,2,4-triazol-3-yl)methyl]quinazoline2,4(1H,3H)-dione (5b) has the best inhibitory activity with 1.25 ± 0.45 µg/mL IC50 value.
Funder
Research Fund of the Recep Tayyip Erdogan University
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
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