Affiliation:
1. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400019, India
Abstract
Abstract:
A rapid and highly efficient methodology for the synthesis of 1, 2, 4-triazolidine-3-thiones
derivatives has been developed in the presence of a catalytic amount of guanidine hydrochloride using
water as a solvent. The reaction of thiosemicarbazide with different aryl aldehydes resulted in the formation
of title compounds in good yields (85-95%) with a convenient reaction time (20-30 min). The
key advantages of this approach include shorter reaction time, energy efficiency, easy work-up procedure,
and wide substrate scope tolerance. Furthermore, the catalyst was recycled without significant
loss of its catalytic activity.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
Cited by
1 articles.
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