Synthesis and Characterization of Some New Spirothiadiazole Oxindoles and their Mannich Bases-Reference-Cited by-同舟云学术

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Synthesis and Characterization of Some New Spirothiadiazole Oxindoles and their Mannich Bases

Published:2022-12 Issue:12 Volume:19 Page:1136-1140
ISSN:1570-1786
Container-title:Letters in Organic Chemistry
language:en
Short-container-title:LOC

Author:

Sim Kooi-Mow¹,Leong Pei-Theng¹,Wong Wai-Sum¹,Teo Kah-Cheng²

Affiliation:

1. Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Jalan Universiti, Bandar Barat, 31900 Kampar, Perak, Malaysia

2. Department of Agricultural and Food Science, Faculty of Science, Universiti Tunku Abdul Rahman, Jalan Universiti, Bandar Barat, 31900 Kampar, Perak, Malaysia

Abstract

Abstract: A series of new spirothiadiazole oxindoles were synthesized by the reaction of 4-amino-5- mercapto-3-[(1H-indol-3-yl)methyl]-1,2,4-triazole and isatin derivatives. The reaction of spiro [indole] thiadiazoles with formaldehyde and piperidine afforded the corresponding Mannich bases. The structures of newly synthesized compounds were characterized by IR, 1D-NMR, 2D-NMR, and LC/MS spectral data.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry,Biochemistry

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