New Bicyclic Lactone by Biotransformation of β-caryophyllene using Aspergillus niger-Reference-Cited by-同舟云学术

New Bicyclic Lactone by Biotransformation of β-caryophyllene using Aspergillus niger

Published:2022-12 Issue:12 Volume:19 Page:1132-1135
ISSN:1570-1786
Container-title:Letters in Organic Chemistry
language:en
Short-container-title:LOC

Author:

Mohammad Mohammad Yasin¹,Al-Dulaimi Qutaiba²,Al-Najdawi Manal²,Al-Hiari Yusuf M.³,Haniffa Haroon M.⁴,Choudhary M. Iqbal⁵

Affiliation:

1. Michael Sayegh Faculty of Pharmacy, Aqaba University of Technology, Aqaba-11191, Jordan

2. Faculty of Pharmacy, Al-Isra University, Amman-11622, Jordan

3. Faculty of Pharmacy, The University of Jordan, Amman-11942, Jordan

4. Department of Chemical Sciences, Faculty of Applied Sciences, South Eastern University, Oluvil, Sri Lanka

5. H.E.J., Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

Abstract

Abstract: Microbial transformation of β-caryophyllene (1) by suspended cell cultures of the plant pathogen fungus Aspergillus niger, resulted in the production of one major metabolite. This metabolite was identified as (3aR,11aS, E)-9-methyl-4-methylene-3a,4,7,10,11,11a-hexahydro-2H-furo[3,2- c]oxecine-2,6(3H)-dione (2), by different spectroscopic methods. Metabolite 2 was found to be a new compound. The proposed pathway for the synthesis of compound 2 was also explained.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry,Biochemistry

Reference7 articles.

1. Choudhary M.I.; Musharraf S.G.; Sami A.; Atta-ur-Rahman. Helv Chim Acta 2004,87(10),2685-2694

2. Legault J.; Pichette A.; J Pharm Pharmacol 2007,59(12),1643-1647

3. Dahham S.S.; Tabana Y.M.; Iqbal M.A.; Ahamed M.B.K.; Ezzat M.O.; Majid A.S.; Majid A.M.; Molecules 2015,20(7),11808-11829

4. Dahham S.S.; Tabana Y.M.; Khadeer Ahamed M.B.; Abdul Majid A.M.S.; Molecules and Medicinal Chemistry 2015,1,1-6

5. Moo C.L.; Yang S.K.; Osman M-A.; Yuswan M.H.; Loh J-Y.; Lim W-M.; Lim S-H-E.; Lai K-S.; Pol J Microbiol 2020,69(1),1-6