Affiliation:
1. Institute of Pharmaceutical Research, GLA University Mathura, Mathura, Uttar Pradesh, India
Abstract
Abstract:
The novel coronavirus disease (COVID-19) emerged in December 2019. It is caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is still existent all over the world.
Researchers worldwide are continuously conducting in silico studies or virtual screening on various
phytochemicals and reporting potential candidates that can be developed against COVID-19 after
in vitro and in vivo validation. Antiviral effects of several phytochemicals have been demonstrated
against different kinds of coronavirus, including SARS-CoV. Using drug repurposing techniques, a
number of phytochemicals have shown substantial antiviral efficacy against COVID 19. This article
reviews the efficacy of lead phytochemicals in computational studies on different important targets of
SARS-CoV-2 like main protease, ACE-2, papain-like protease, spike protein, nsp-1, nsp-15, RdRp,
MTase, helicase, cathepsin, TMPRSS-2. This review discusses potential application of these phytochemicals,
which can guide medicinal chemists to choose phytochemicals to proceed with further
in vitro and in vivo testing for SARS-CoV-2, which may eventually lead to an effective therapeutic
agent and thus can be used to control the current ongoing pandemic.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry