Synthesis and Evaluation of Aromatic Surfactants as Potential Antibacterial and Cytotoxic Agents-Reference-Cited by-同舟云学术

Synthesis and Evaluation of Aromatic Surfactants as Potential Antibacterial and Cytotoxic Agents

Published:2019-04-23 Issue:6 Volume:16 Page:478-484
ISSN:1570-1786
Container-title:Letters in Organic Chemistry
language:en
Short-container-title:LOC

Author:

Barrantes Kenia¹,Fuentes Mary²,Chacón Luz¹,Achí Rosario¹,Granados-Zuñiga Jorge³,Alvarado María José⁴,Somarribas Luis³,Vázquez-Tato José⁵,Vázquez-Tato M. Pilar⁵,Seijas Julio A.⁵,Tellini Víctor Soto⁴

Affiliation:

1. Health Research Institute (INISA), University of Costa Rica, San José 2060, Costa Rica

2. MHIRT Program, University of Texas at El Paso(UTEP), El Paso, TX 79968, United States

3. School of Medicine, University of Costa Rica, San Jose 2060, Costa Rica

4. School of Chemistry, University of Costa Rica, San Jose 2060, Costa Rica

5. Facultad de Ciencias, Departamento de Quimica Organica, Universidad de Santiago de Compostela, Santiago, Spain

Abstract

Two ether and one ester derivatives of the 4-nitro-3-hydroxybenzoic acid were synthesized and characterized. The in vitro antimicrobial and cytotoxic activities of the three novel compounds were also evaluated. The aromatic derivatives showed antibacterial activity against one of the four microorganisms tested and two compounds (C8 and NOBA) had a lower IC50 in HeLa cells.

Funder

Ministerio de Ciencia y Tecnología

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry,Biochemistry

Reference33 articles.

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