Affiliation:
1. Department of Chemistry, Faculty of Arts and Sciences, Recep Tayyip Erdogan University, 53100 Rize, Turkey
2. Department of Biology, Faculty of Arts and Sciences, Recep Tayyip Erdogan University, 53100 Rize, Turkey
Abstract
Pyrazoles, Schiff bases and the quaternary ammonium compounds (QAC) such as N-alkyl
substituted azachalcones are the important group of chemical individuals with widespread usage in
many fields of science. In particular, these compounds have proven biological activities. In addition,
the emergence of resistance against antibiotics used is the cause of an increasing necessity of new effective
substances. Therefore, new N-alkyl substituted derivatives (4-7), 1,3,5-trisubstituted-2-
pyrazoles (8-10) and Schiff bases (11-13) with biological activities such as phenolic. antioxidants or
QAC were synthesized, starting from azachalcones. The structures of the compounds were elucidated
with spectral methods including IR, 1H-NMR, 13C-NMR, COSY spectral data and elemental analyses.
The prepared compounds were evaluated for antibacterial activity against four Gram-positive bacteria,
and four Gram-negative bacteria. The minimum inhibitory concentration (MIC) of the N-alkylated
azachalcone derivatives 5 and 7 (7.8 mg/mL) showed strong antimicrobial activities, especially against
Bacillus cereus. Antioxidant capacities of the synthesized compounds were determined by using CUPRAC
and FRAP methods. As a result, compound 9 was observed to be more effective than other
compounds.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
Cited by
9 articles.
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