Affiliation:
1. Department of Chemistry, Varamin-Pishva Branch, Islamic Azad University, Varamin, Iran
Abstract
Abstract:
Predicting the adsorption behavior of the 6-Mercaptopurine (MCP) anticancer drug upon
the polyoxazolinenano-carrier was investigated using DFT and TD-DFT methods by B3LYP/6-31G*
level in the gas phase and water solution. Based on the thermochemical parameters, the MCP/polymer
complex in the solvent water is more stable rather than the gas phase. The adsorption energies of the
MCP/polymer complex displayed that the adsorption process is exothermic. The UV/Vis absorption
and IR spectra analysis were calculated to investigate the changes happening in the interaction of the
MCP with the polymer. FMO analysis indicated that the energy gap (Eg) of the polymer decreased after
the adsorption process. Electronic properties and MEP analysis were also studied. Based on NBO
analysis and charge difference (ΔN), the charge transfer in MCP/polymer occurs essentially from the
polymer to the MCP drug, which is consistent with the results of NBO analysis. It is predicted that the
POZ polymer can be used as a drug delivery system for MCP drug.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
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