One-pot of Three-component Synthesis of Novel Biologically Important 5-Amino-1,3-diaryl-1H-pyrazole-4-carbonitriles Using L-Proline Catalyst and their Antimicrobial Activity

Author:

Heravi Mohammad Reza Poor1,Danafar Mahdis1,Heravi Niloofar Poor2

Affiliation:

1. Department of Chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, Iran

2. Department of Biochemistry, School of Medicine, Anzali International Campus, Guilan University of Medical Sciences, Rasht, Iran

Abstract

An expeditious three-component synthesis of various biologically important heterocyclic compounds 5-amino-1,3-diaryl-1H-pyrazole-4-carbonitriles by condensation of aryl aldehydes, malononitrile and phenylhydrazine derivatives is described. This greener protocol was catalyzed by L-Proline and proceeded efficiently in solvent at room temperature within 2-15 min.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry,Biochemistry

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