Interpenetrating Polymer Networks of Polyacrylamide with Polyacrylic and Polymethacrylic Acids and Their Application for Modified Drug Delivery - a Flash Review

Author:

Simeonov Marin1ORCID,Kostova Bistra2,Vassileva Elena1

Affiliation:

1. Laboratory on Structure and Properties of Polymers, Faculty of Chemistry and Pharmacy, University of Sofia, 1, J. Bourchier blvd., Sofia 1164, Bulgaria

2. Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, 2, Dunav str., Sofia 1000, Bulgaria

Abstract

Abstract: Polyacrylic and polymethacrylic acids in combination with polymers such as polyacrylamide provide the ability for controlled and sustained drug delivery since they represent pH- and temperature responsiveness. In addition, the synthesis techniques can be used to develop a higher level of supramolecular structures as the interpenetrating polymer networks – as bulk hydrogels or micro-/nanogels. They can provide the opportunity to organize and build up state-of-the-art carriers for different types of drugs thus providing ability to control their loading capacity and drug release performance. This flash review aims to summarize the efforts for synthesis of such interpenetrating polymer networks, their properties and to demonstrate the authors contributions into this field.

Funder

Bulgarian National Science Foundation

Bulgarian Ministry of Education and Science

Publisher

Bentham Science Publishers Ltd.

Subject

Biomedical Engineering,Pharmaceutical Science

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