An Outlook Towards Nano-Sponges: A Unique Drug Delivery System and its Application in Drug Delivery

Abstract

Abstract: Nanosponges are colloidal and crosslinked nanocarriers consisting of a solid mesh-like network with nanocavities to encompass various types of substances like antineoplastic, proteins, peptides, volatile oil, DNA and then incorporated into topical medications that are mainly formulated like gels, creams, lotions, ointments, liquid and powders etc., for topical drug delivery system. In the polymeric construction of nanosponges, the release of enthalpy-rich water molecules accounts for high complexation efficiency for different molecular substances. The benefits of nanosponges involve the extended and controlled release of encapsulated particles with excellent competence and great stability. Nanosponges assume a significant part to new varieties of medicaments, beautifiers, farming, horticulture, high atomic weight containing proteins, innovative fire retardants, gas transporters, and water filters. Nanosponges are a novel technology that offers controlled and targeted drug delivery by different itineraries like oral, parenteral, and topical routes. Nanosponges are an effective transporter for biologically active ingredients; therefore, it is broadly employed in anti-cancer, antiviral, antiplatelet, antilipidemic therapy. This review article gives attention to the general introduction, merits and demerits, classification, characteristic features, nanosponges development procedures, numerous factors affected by nanosponge formulation, evaluation parameters, and applications in the medicinal industry.