Affiliation:
1. Department of Plastic Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433, China
2. School of
Life Sciences and Technology, Tongji University, Shanghai, 200092, China
Abstract
Abstract:
The surface proteins on cell membranes enable the cells to have different properties, such as
high biocompatibility, surface modifiability, and homologous targeting ability. Cell-membrane-derived
vesicles have features identical to those of their parental cells, which makes them one of the most promising
materials for drug delivery. Recently, as a result of the impressive effects of immunotherapy in
cancer treatment, an increasing number of researchers have used cell-membrane-derived vesicles to
enhance immune responses. To be more specific, the membrane vesicles derived from immune cells,
tumor cells, bacteria, or engineered cells have the antigen presentation capacity and can trigger strong
anti-tumor effects of the immune system. In this review, we first indicated a brief description of the
vesicles and then introduced the detection technology and drug-loading methods for them. Secondly, we
concluded the characteristics and applications of vesicles derived from different sources in cancer immunotherapy.
Funder
Shanghai Municipal Commission of Health and Family Planning Clinical Research Program
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.