Affiliation:
1. Pharmacologist, Dubai Health Authority, Dubai, UAE
2. Department of Pharmacology, J.K.K. Nattraja College of Pharmacy,
Komarapalayam-638 183, India
3. Excel College of Pharmacy, Pallakkapalayam-637 303, Komarapalayam, India
4. Department of Pharmacy, Libyan Academy for Postgraduate Studies, Tripoli, Libya
Abstract
Abstract:
Around 3500 laboratory-confirmed cases of monkeypox infection, from 42 non-endemic
countries have been reported to World Health Organization (WHO), during the current multicountry
monkeypox outbreak. As of now, patients with monkeypox infection are managed symptomatically
with supportive care. Hence, our current review focuses on the analysis of the pharmacotherapeutic
potentials of black seeds (N. sativa). The literature was searched in web-based databases
including web of science, Medline/PMC/PubMed, Embase, EBSCO, Google Scholar, Science
Direct, and reference lists to identify relevant publications. Several clinical, animal, in-vivo,
in-vitro, and in-silico studies have confirmed the antiviral efficacy of N. sativa against various viruses.
In addition, previous research have demonstrated the analgesic, anti-inflammatory, antibacterial,
antioxidant, and immunomodulatory effects of Black seeds (N. sativa), which would help to
alleviate the signs, symptoms, and complications associated with monkeypox infection. In consequence,
black seeds (N. sativa) could be added as an adjuvant therapy along with repurposed/
investigational antiviral drugs and supportive care in the management of patients with monkeypox
infection in early stages to prevent inflammatory conditions and secondary bacterial infections.
The safety and efficacy of Black seeds (N. sativa) in the management of monkeypox infection
would further be established by future randomized controlled clinical trials.
Publisher
Bentham Science Publishers Ltd.
Subject
Complementary and alternative medicine,Drug Discovery
Cited by
1 articles.
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