Affiliation:
1. Department of Zoology, Molecular Cancer Genetics & Translational Research Lab, Section of Genetics, Aligarh Muslim
University, Aligarh-202002, UP, India
Abstract
Background:
Cancer is a global health issue and economic burden with a continuous
increase in incidence and mortality. Over the years, the underlying molecular mechanism of cancers
was thoroughly researched, leading to multiple drugs' development. Unfortunately, most
drugs have some serious drawbacks, such as therapy resistance and toxicity. Epidemiological studies
have shown that a diet rich in fruits and vegetables has cancer prevention properties, which
shifted the attention to the potential role of phytochemicals in anti-carcinogenic activity.
Objective:
To review the present status of phytochemicals research and patents in cancer prevention
and chemosensitization.
Methods:
We explored the relevant published articles and patents to review the phytochemicals
showing cancer preventive role in preclinical settings from 1997 onwards.
Results:
We summarise the role of phytochemicals on anti-carcinogenic, anti-inflammatory, antiproliferative,
anti-metastatic, and pro-apoptotic activities in both in vitro and in vivo. Thus, phytochemicals
might be an excellent chemosensitizing agent against chemoresistant cells and possibly
one of the safest and most effective options for cancer therapy. However, one of the limitations of
phytochemicals is their poor bioavailability and rapid excretion. Several analogs have been introduced
to increase bioavailability, better biological efficacy, absorption, and retention. In fact, various
phytochemicals and their analogs have been patented for their anti-cancerous properties.
Conclusion:
This mini-review discusses various phytochemicals and their anti-cancerous and
chemosensitizing roles. Due to their clinical relevance, recent trends in phytochemical extraction
and exploration have shown that more and more phytochemicals are being patented.
Funder
UGC, University Grants Commission
DST-SERB, New Delhi, India
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Cancer Research,Drug Discovery,Oncology,General Medicine
Cited by
6 articles.
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