Affiliation:
1. "VINČA" Institute of Nuclear Sciences - National Institute of thе Republic of Serbia, University of Belgrade, Department of Physical Chemistry, Belgrade, Serbia
2. Serbian Academy of Sciences and Arts, Belgrade, Serbia
3. "VINČA" Institute of Nuclear Sciences - National Institute of thе Republic of Serbia, University of Belgrade, Department of Radiobiology and Molecular Genetics, Belgrade, Serbia
Abstract
Background:
Gentiana lutea (GL), commonly known as yellow gentian, bitter root, and bitterwort,
belongs to family Gentianaceae. GL belongs to genus Gentiana, which is a rich natural source
of iridoids, secoiridoids, xantones, flavonoids, triterpenoids, and carbohydrates. Medicinal plants from
Gentiana species have anti-oxidant, anti-inflammatory, anti-mitogenic, anti-proliferative, and lipidlowering
effects, as well as a cardioprotective, hypotensive, vasodilator and anti-platelet activities.
Objective:
We reviewed the recent literature related to the effects of Gentiana species, and their active
components on vascular diseases.
Methods:
Data used for this review were obtained by searching the electronic database [PUBMED/
MEDLINE 1973 - February 2020]. The primary data search terms of interest were: Gentiana
lutea, Gentienacea family, phytochemistry, vascular diseases, treatment of vascular diseases, antioxidant,
anti-inflammatory, anti-atherogenic.
Conclusion:
Gentiana species and their constituents affect many different factors related to vascular
disease development and progression. Therefore, Gentiana-based therapeutics represent potentially useful
drugs for the management of vascular diseases.
Publisher
Bentham Science Publishers Ltd.
Subject
Cardiology and Cardiovascular Medicine,Pharmacology
Cited by
7 articles.
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