Targeted Treatment of Various Cancers using Radionuclide: Advancement and Prospective

Abstract

Abstract: Radiopharmaceutical therapy is a novel targeted cancer treatment approach that is presently being investigated and developed. Radiation is administered in radiopharmaceutical therapy by selectively binding drugs to target cancer cells. Since most radioactive materials used in radiation therapy emit photons, it is possible to monitor the movement of drugs in a non-invasive manner. Compared to other systemic cancer treatments, Radiopharmaceutical therapy has shown effectiveness with minimal adverse effects. Radiopharmaceutical treatment has shown a promising safety profile and potential effectiveness against various types of cancers. Additionally, it has been successful in distinguishing between cancerous and non-cancerous tissues. Radiopharmaceutical therapy offers numerous advantages compared to other techniques. Radiopharmaceuticals are chemical substances containing a radioactive isotope that can release radiation. This radiation can be identified and employed for medical imaging or as a therapy for cancer. Several cancer treatment methods utilize radiopharmaceuticals, such as radioimmunotherapy, radiolabeled peptides, radiolabeled small molecules, bone-targeted radiopharmaceuticals, and others. This review aims to comprehensively analyze the fundamental principles, recent advancements in clinical practice, and an in-depth understanding of radiotherapy in cancer management.