Affiliation:
1. Department of Physiology, All India Institute of Medical Sciences, Bhubaneswar, India
2. Department of Medicine, All
India Institute of Medical Sciences, Bhubaneswar, India
Abstract
Abstract:
Sarcopenia is a disease characterized by a gradual decline in skeletal muscle mass and
strength that accompanies the normal aging process. The disease is associated with various adverse
health outcomes in the geriatric population, such as prolonged hospital admission, disability, poor
quality of life, frailty, and mortality. Factors involved in the development of age-related sarcopenia
include anorexia, hormone level alterations, decreased neural innervation, low muscular blood
flow, cytokine dysregulation, altered mitochondrial activity, genomic instability, intracellular proteolysis,
and insulin resistance. Understanding the underlying mechanisms may facilitate the development
of efficient prophylactic and therapeutic strategies to improve the quality of life in elderly
individuals. Thus, the present review highlights literature regarding the mechanism of sarcopenia
development in elderly patients.
Publisher
Bentham Science Publishers Ltd.
Cited by
7 articles.
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