Affiliation:
1. Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P., 221005,
India
Abstract
Abstract:
Chalcones are flavonoid-related aromatic ketones and enones generated from plants. The
chalcones have a wide range of biological activities, such as anti-tumor, calming, and antimicrobial
activities. In the present review, we have focused on the recently published original research articles
on chalcones as a unique antibacterial framework in medicinal chemistry.
:
Chalcones are structurally diverse moieties and can be split into simple and hybrid chalcones, with
both having core pharmacophore 1,3-diaryl-2-propen-1-one. Chalcones are isolated from natural
sources and also synthesized by using various methods. Their structure-activity relationship, mechanisms,
and list of patents are also summarized in this paper. This review article outlines the currently
published antimicrobial chalcone hybrids and suggests that chalcone derivatives may be potential
antimicrobial agents in the future.
Funder
Institute of Eminence
Indian Council of Medical Research (ICMR), India
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine