Affiliation:
1. School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China
2. College of Pharmacy, Jining Medical University, Shandong Province, 276826, China
Abstract
Ginseng is a traditional medicine with a complex chemical composition, wide bioactivity
and unique pharmacological action. Many studies have confirmed that ginsenosides are the active ingredients
of ginseng, and ginsenosides have always been the focus of different researchers. With the
development of modern separation and analysis technology, more than 150 kinds of ginsenosides have
been isolated. The ginsenosides Rb1, Rb2, Rc, Rg1 and Re account for more than 80% of total ginsenosides,
and other saponins, such as Rd, Rg3 and Rh2, which are minor constituents, accounting for
only a small portion of the total amount. In recent years, ginsenosides have been found to possess
strong pharmacological activities, such as antioxidation, clearing of oxygen free radicals, reducing calcium
overload and anti-apoptosis. Ginsenosides play a protective role in ischemia-reperfusion injury.
This paper reviews the protective effects of ginsenosides on myocardial ischemia and ischemiareperfusion
injury.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
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