Affiliation:
1. Medical College, China Three Gorges University, Yichang 443002, China
2. Hubei Key Laboratory of Tumor Microenvironment
and Immunotherapy, China Three Gorges University, Yichang 443002, China
3. Third-grade Pharmacological
Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three
Gorges University, Yichang 443002, China
Abstract
Abstract:
Long non-coding RNA has attracted the interest of researchers as a relevant factor that can
influence human cancers. As an oncogene and suppressor gene, it has numerous pathways and is
closely related to the pathophysiology of human diseases. Meanwhile, it may become a novel treatment
option and target for tumor treatment. CRNDE is the gene symbol for Colorectal Neoplasia Differentially
Expressed (non-protein-coding) since it was found to be considerably higher in colorectal
cancer when it was first discovered. It's transcribed from human chromosome 16. Many studies have
shown that it is intimately linked to the etiology of many tumors and malignancies. According to the
paper, the biological function and pathophysiological mechanism of CRNDE in tumors have been
studied extensively in recent years. PubMed served as an essential platform for conducting literature
searches and related analyses. CRNDE, a long non-coding RNA closely related to tumors, was highly
expressed in many tumor cells. There were various underlying mechanisms affecting the progression
of CRNDE-regulated tumorigenesis, including hepatocellular carcinoma, gastric cancer, prostate carcinoma,
oral squamous cell carcinoma, breast cancer, thyroid cancer, myeloma, leukemia, melanoma,
colorectal cancer, glioblastoma, osteosarcoma, cervical cancer, intrahepatic cholangiocarcinoma, nonsmall
cell lung cancer, hepatoblastoma cell tumor, abdominal aortic aneurysm, nasopharyngeal carcinoma,
bladder cancer, Wilms tumor, medulloblastoma, pancreatic cancer, gallbladder cancer, ovarian
cancer, and renal cell carcinoma. CRNDE is involved in the processes of proliferation, migration, invasion,
and inhibition of apoptosis of various cancer cells.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
1 articles.
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1. Advances in epigenetic modifications and cervical cancer research;Biochimica et Biophysica Acta (BBA) - Reviews on Cancer;2023-05