Affiliation:
1. College of Plant Protection,
Northwest A&F University, Yangling 712100, Shaanxi Province, P. R. China
2. School of Marine Sciences, Ningbo University, Ningbo 315211, Zhejiang Province, P. R. China
Abstract
Abstract:
Natural products are an invaluable source for the discovery of drug and pesticide candidates.
Piperine, a simple and pungent alkaloid, is isolated from several plants of Piperaceae.
Piperine and its derivatives displayed a wide range of biological properties, such as antitumor activity,
anti-inflammatory activity, antioxidant activity, neuroprotective activity, insecticidal activity,
etc. In recent years, lots of works focused on the biological activities, mechanisms of action,
total synthesis, and structural modifications of piperine and its derivatives have been conducted.
To the best of our knowledge, however, few review articles related to the biological activities,
mechanisms of action, total synthesis, and structural modifications of piperine and its derivatives
have been reported to date. Therefore, this review summarizes the research advances (from 2014
to 2020) of piperine and its derivatives regarding bioactivity, mechanisms of action, total synthesis,
and structural modifications. Meanwhile, the structure-activity relationships of piperine and
its derivatives are also discussed.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine