The Research Progress of Direct Thrombin Inhibitors-Reference-Cited by-同舟云学术

The Research Progress of Direct Thrombin Inhibitors

Published:2020-11-10 Issue:16 Volume:20 Page:1574-1585
ISSN:1389-5575
Container-title:Mini-Reviews in Medicinal Chemistry
language:en
Short-container-title:MRMC

Author:

Sun Zhi-Gang¹^ORCID,Yang-Liu ¹,Zhang Jin-Mai²^ORCID,Cui Shi-Chang¹,Zhang Zhi-Gang³,Zhu Hai-Liang⁴^ORCID

Affiliation:

1. Central Laboratory, Linyi Central Hospital, No.17 Jiankang Road, Linyi 276400, China

2. Room 205, BIO-X white house, Shanghai Jiao Tong University, No.1954 Huashan Road, Shanghai 200030, China

3. Department of Cardiovascular Medicine, Linyi Central Hospital, No.17 Jiankang Road, Linyi 276400, China

4. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, No.163 Xianlin Road, Nanjing 210023, China

Abstract

Blood coagulation is the process of changing the blood from the flowing state to the gel state. It is an important part of the hemostatic function. Coagulation is a process by which a series of coagulation factors are sequentially activated, and finally thrombin is formed to form fibrin clot. Direct thrombin inhibitors are important anticoagulant drug. These drugs can selectively bind to the active site of thrombin, inhibit thrombin activity, have strong action and high specificity, and have important significance in the clinical treatment of thrombus diseases. Some of them come from natural products of animals or plants, and many of them have been applied in the clinic. The other part is derived from the design, synthesis and activity studies of small molecule inhibitors. This review discusses the progress of direct thrombin inhibitors in recent years.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology,General Medicine

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