Affiliation:
1. Department of Applied Chemistry and Chemical Engineering, University of Chittagong, Chattogram, Bangladesh
2. Molecular Modeling Drug-design and Discovery Laboratory, Pharmacology Research Division, BCSIR Laboratories Chattogram, Bangladesh Council of Scientific and Industrial Research, Chattogram, Bangladesh
Abstract
Background:
Adhatoda vasica (Nees.) of the family Acanthaceae has been used in the
Southeast tropical zone as it is efficacious against headache, colds, cough, whooping cough, fever,
asthma, dyspnea, phthisis, jaundice, chronic bronchitis, and diarrhea. It exhibits commendable pharmacological
activities.
Objective:
The aim of the review is to provide a systematic overview of pharmacological activities with toxicity and clinical assessment, phytochemistry of A. vasica along with its characterization, geographical observation, phenology, traditional uses as well as an organized representation of the findings.
Methods:
The overall information of A. vasica was collected from various resources, including books,
review papers, research papers, and reports which were obtained from an online search of globallyaccepted
scientific databases. ChemDraw software was used to draw the compound’s structure.
Results:
Phytochemical review on A. vasica has led to the collection of 233 compounds of different
types such as alkaloids, flavonoids, essential oils, terpenoids, fatty acids, phenols, etc. It is a promising
source of potential phytopharmaceutical agent that exhibits diverse pharmacological activities,
including antibacterial, antifungal, hepatoprotective, anti-ulcer, abortifacient, antiviral, antiinflammatory,
thrombolytic, hypoglycemic, anti-tubercular, antioxidant, and antitussive activities.
Conclusions:
The sufficient number of studies on ethno-pharmacology, traditional uses and pharmacological activities of A. vasica are conducted. Furthermore, it is necessary to study the activity of chemical constituents for new drug design and discovery from natural products.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
13 articles.
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