Affiliation:
1. Department of Horticulture, Science and Research Branch, Islamic Azad University, Tehran, Iran
2. Halal Research Center of IRI, FDA, Tehran, Iran
Abstract
:
Peptic Ulcer Disease (PUD) is the most common disorder of the stomach and duodenum,
which is associated with Helicobacter pylori infection. PUD occurs due to an imbalance between offensive
and defensive factors and Proton Pump Inhibitors (PPI), Nonsteroidal Anti-Inflammatory
Drugs (NSAIDs) and antibiotics are frequently used for the treatment. Recently, medicinal plants have
emerged as efficacious, safe and widely available alternative therapies for PUD. The aim of this review
was to study the medicinal plants and phytochemicals, which have been used for PUD treatment to
evaluate the potential role of natural compounds to develop herbal remedies for PUD. Information was
obtained using a literature search of electronic databases, such as Web of Science, Google Scholar,
PubMed, Sci Finder, Reaxys and Cochrane. Common and scientific names of the plants and keywords
such as ‘peptic ulcer’, ‘gastric ulcer’, ‘stomach ulcer’ and ‘duodenal ulcer’ were used for search. Eventually,
279 plants from 89 families were identified and information on the plant families, part of the
plant used, chemical constituents, extracts, ulcer model used and dosage were abstracted. The results
indicated that most of the anti-PUD plants were from Asteraceae (7.1%) and Fabaceae (6.8%) families
while flavonoids (49%), tannins (13%), saponins (10%) and alkaloids (9%) were the most common
natural compounds in plants with anti-PUD activity.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
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