Water-Mediated Synthesis, Antibacterial and Antioxidant Evaluation of New Fused Pyrimido-pyrimidine and Pyrimido-purines Derived From Nucleobases-Reference-Cited by-同舟云学术

Water-Mediated Synthesis, Antibacterial and Antioxidant Evaluation of New Fused Pyrimido-pyrimidine and Pyrimido-purines Derived From Nucleobases

Published:2023-07-20 Issue: Volume:10 Page:
ISSN:2213-3461
Container-title:Current Green Chemistry
language:en
Short-container-title:CGC

Author:

Bouguessa Ichrak¹^ORCID,Aber Mohamed²³,Khier Nawal⁴^ORCID,Dehamchia Mohamed⁵^ORCID,Bayou Samir⁶^ORCID,Régaïnia Zine⁷^ORCID

Affiliation:

1. Department of Biology, University of El Oued, PO Box 789, 39000, Algeria.

2. Marisa Kozlowski Research Group, Chemistry Department, University of Pennsylvania, USA

3. Laboratoire des Ecosystèmes Aquatiques et Terrestres, Mohamed Cherif Messadia University, Souk Ahras 41000, Algeria

4. Laboratory of Bioinformatics, Applied Microbiology and Biomolecules, University of Boumerdès, 35000 Bumerdes, Algeria

5. Department of Biology, University of El Oued, PO Box 789, 39000, Algeria

6. LEPCMAE, Faculty of Chemistry, USTHB, PO Box 32, El-Alia 16025 Bab-Ezzouar, Algeria.

7. Faculty of Sciences and Technology, Mohamed Cherif Messadia University - Souk Ahras-41000- Algeria

Abstract

Introduction: A simple and eco-friendly synthesis of novel substituted pyrimido[1,6-a]pyrimidine, pyrimido[1,2-g]purine, and pyrimido[2,1-e]purine was accomplished by refluxing of nucleobases (cytosine, adenine or guanine) and dibenzalacetone (DBA) in water using NaOH as a catalyst. Method: The molecular structures of the resulting products were characterized by infrared spectroscopy (FT-IR), mass spectrometry, and proton (1H) and carbon (13C) nuclear magnetic resonance (NMR). Result: The antibacterial activity of the newly fused heterocycles was assayed against the Gram-positive bacterium Staphylococcus aureus (ATCC 6538) and Gram-negative Escherichia coli (ATCC 8737) using gentamicin as a standard commercially available antibiotic. Conclusion: In addition, the antioxidant capacity was screened using the 2,2-diphenyl-2-picrylhydrazyl hydrate (DPPH•) and the 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS+•) radicals scavenging assay.

Publisher

Bentham Science Publishers Ltd.

Subject

General Medicine

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthetic approaches for novel annulated pyrido[2,3-d]pyrimidines: Design, Structural Characterization, Fukui functions, DFT Calculations, Molecular docking and Anticancer efficiency;Journal of Molecular Structure;2024-12