Affiliation:
1. Department of Training and Development, Orchid Pharma Ltd., 138-149, SIDCO Industrial Estate, Alathur, Chennai- 603 110, Tamil Nadu, India
2. Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India
Abstract
:
The benzofuranyl motif present in compounds exhibits various medicinal properties and
non-drug applications. These derivatives are naturally occurring compounds or synthetic materials,
which cover a broad spectrum of pharmacological activities like anti-inflammatory, anti-diabetic, anti-
depressant, anti-HIV, anti-microbial, anti-proliferative, anti-convulsant, cytotoxic, analgesic, etc.
Few of the commercially interesting compounds from this class are, ailanthoidol (anti-inflammatory),
amiodarone, dronedarone, celivarone (anti-arrhythmic), bufuralol (muscular airways relaxant), morphine,
5-(2-aminopropyl)benzofuran; 5-APB, 6-(2-aminopropyl)benzofuran; 6-APB (CNS), rifampicin
(antibiotic), etc., whereas, some of the non-drug applications are in perfumery industry (bergapten)
and as tannin activators in sunscreen preparations (psoralen, 8-methoxypsoralen, and angelicin).
Considering these interesting biological activities and commercial utilities, a review on the synthetic
aspects of this privileged scaffold was attempted. For the benefit of natural product-based drug discovery,
available sources of these derivatives, extraction process and reported biological activities
have also been outlined in this review.
Publisher
Bentham Science Publishers Ltd.
Reference155 articles.
1. Brenda M.; René T.; Michelle D.S.P.; Katherine S.; Adriana A.; Raúl C.; Pablo C.; In vitro antiproliferative activity of 3 H-spiro [1-benzofuran-2,1′-cyclohexane] derivatives. Bol Latinoam Caribe Plantas Med Aromat 2011,3,281-288
2. Bakr F.; Wahab A.; Aziz H.A.A; Ahmed S.M.; Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1,3-thiazol-2-yl]-1H-pyrazoles. Eur J Med Chem 2009,44,2632-2635
3. Jerzy K; Mariol K; Bożena K; Joann S; Iren W; Synthesis and preliminary evaluation of the antimicrobial activity of selected 3-benzofurancarboxylic acid derivatives. Molecules 2010,15,4737-4749
4. Vrushali P.; Ashish A.; Shantanu P.; Bobade A.S.; Chowdhary A.S.; Synthesis of 5-aryl-3-(5-bromo-3-benzofuran-2-yl)-1-pyrazole as antimicrobial agent. IOSR J Phar Biol Sci 2013,8,4-8
5. Sangeetha M.; Brijendra K.S.; Tribhuvan S.; Chetan M.B.; Mudshinge S.R.; In-vitro anti-inflammatory studies of 3-(1-Benzofuran-2-yl)-5-(substituted aryl) isoxazole. Int J Res Pharm Biomed Sci 2011,2,1203-1205
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