Affiliation:
1. Departamento de Ciencias Químico Biológicas, Universidad de las Américas Puebla, Cholula, Puebla, México
Abstract
Abstract:
Even though there has been an important evolution in the synthesis of oligosaccharides, the
efficient and stereoselective study of glycosidic bonds through non-toxic, moderate, and inexpensive
techniques is one of the most challenging fields in organic synthesis. Glycosyl reactions play a
fundamental role in biological material and structure-activity relationships, having numerous medicinal
chemistry applications. For this, interesting strategies have evolved over the years to control the
stereoselectivity of glycosidic bonds, including the manipulation of different reaction elements, mainly
promoters or catalysts, but also involving the nature of donors and solvents. This review looks at
glycosylation methodologies in the last decade resulting in the specific formation of alpha or beta
glycosidic bonds.
Publisher
Bentham Science Publishers Ltd.