Affiliation:
1. Department of Chemistry, Banasthali Vidyapith, Banasthali-304022, India
2. Department of Pharmacy, Banasthali Vidyapith, Banasthali-304022, India
Abstract
1, 3, 5-Triazine (s-Triazine) is a versatile nucleus to design and develop potent bioactive
molecules for drug discovery, particularly in cancer therapy. The aim of this review is to present the
most recent trends in the field of synthetic strategies made for functionalized triazine derivatives active
against cell proliferation. This review article covers the synthesis of aryl methylamino, morpholino,
triamino substituted triazines, antimitotic agents coupled triazines and many more. Many 1,3,5-
triazine derivatives, both hetero-fused and uncondensed, have shown remarkable antitumor activities.
We have highlighted various derivatives with 1, 3, 5-triazine core targeting different kinases with an
aim to help researchers for developing new 1, 3, 5-triazine derived compounds for antitumor activity.
Publisher
Bentham Science Publishers Ltd.
Cited by
6 articles.
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1. Synthesis, crystal structure, and DFT study of (E)-N2,N2-dimethyl-6-styryl-1,3,5-triazine-2,4-diamine and (E)-N-(4-(dimethylamino)-6-styryl-1,3,5-triazin-2-yl) acetamide;Molecular Crystals and Liquid Crystals;2023-07-20
2. Molecular modeling and biological investigation of novel s-triazine linked benzothiazole and coumarin hybrids as antimicrobial and antimycobacterial agents;Journal of Biomolecular Structure and Dynamics;2023-05-22
3. Metal-catalyzed synthesis of triazine derivatives;Monatshefte für Chemie - Chemical Monthly;2022-08
4. Direct α-methylenation of triazines to terminal olefins with DMA;New Journal of Chemistry;2022
5. Synthesis, Biological and In Silico Studies of a Tripodal Schiff Base Derived from 2,4,6-Triamino-1,3,5-triazine and Its Trinuclear Dy(III), Er(III), and Gd(III) Salen Capped Complexes;Molecules;2021-07-20