Synthetic Methods of 1H-Pyrazolo[1,2-b]Phthalazine Derivatives-Reference-Cited by-同舟云学术

Synthetic Methods of 1H-Pyrazolo[1,2-b]Phthalazine Derivatives

Published:2023-11 Issue:22 Volume:26 Page:2055-2069
ISSN:1385-2728
Container-title:Current Organic Chemistry
language:en
Short-container-title:COC

Author:

Khidre Rizk E.¹^ORCID,Mostafa Mohamed S.²^ORCID,Mukhrish Yousef E.²,Salem Mounir A.³^ORCID,Behalo Mohamed S.⁴

Affiliation:

1. National Research Centre, Chemical Industry Research Institute, Dokki, Giza, P.O. Box 12622, Egypt

2. Department of Chemistry, Faculty of Science, Jazan University, Jazan, P.O. Box 45142, Saudi Arabia

3. Synthetic Heterocycles Laboratory, Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, P.O. Box 11566, Egypt

4. Department of Chemistry, Faculty of Science, Benha University, Benha, P.O. Box 13518, Egypt

Abstract

Abstract: This review deals with the synthetic methods of pyrazolo[1,2-b]phthalazine derivatives using one-pot multi-component reactions via modern and traditional methods. The synthetic methods are subdivided into groups according to the type of reactants e.g (1) one-pot three-component reaction of 2,3-dihydrophthalazine-1,4-dione, aldehydes and acetonitriles; (2) one-pot three-component reaction of 2,3-dihydrophthalazine-1,4-dione, aldehydes and aroyl acetonitriles; (3) one-pot three-component reaction of 2,3-dihydrophthalazine-1,4-dione, aldehydes and acetylacetone or 4-hydroxy-2H-chromen-2-one or acetylene derivatives; (4) one-pot four-component condensation reaction of phthalimide, hydrazine hydrate, aldehydes and acetonitriles; (5) one-pot four-component reaction of phthalic acid, hydrazine hydrate, indole-3- carbaldehyde and acetonitriles; and (6) one-pot three-component condensation reaction of 2,3- dihydrophthalazine-1,4-dione, aldehyde, and dimedone derivatives. Moreover, the various methods were reported.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

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