Detection, Identification and Structural Elucidation of Flavonoids using Liquid Chromatography Coupled to Mass Spectrometry

Author:

Wojtanowski Krzysztof Kamil1ORCID,Mroczek Tomasz1ORCID

Affiliation:

1. Independent Laboratory of Natural Product Chemistry, Chair of Pharmacognosy, Medical University of Lublin, 1 Chodzki Street, 20-093 Lublin, Poland

Abstract

Flavonoids are one of the most common secondary metabolites occurring in plants. Their activity in the Central Nervous System (CNS) including sedative, anxiolytic, anti-convulsive, anti-depressant and neuro-protective actions is well known and documented. The most popular methods for detection, identification and structural elucidation of flavonoids are these based on Nuclear Magnetic Resonance (NMR) and mass spectrometry (MS). NMR allows rapid, high throughput analysis of crude extracts and also gives stereochemical details about identified substances. However, these methods are expensive and less sensitive than MS-based techniques. Combining High Performance Liquid Chromatography (HPLC) with MS detection gives the most powerful tool for analysis of flavonoids occurring in plants. There is a lot of different approaches to use LC/MS based techniques for identification of flavonoids and this short review shows the most important.

Funder

National Centre for Research and Development

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

Reference81 articles.

1. Jäger A.K.; Saaby L.; Flavonoids and the CNS. Molecules 2011,16(2),1471-1485

2. Fernández S.P.; Wasowski C.; Loscalzo L.M.; Granger R.E.; Johnston G.A.R.; Paladini A.C.; Marder M.; Central nervous system depressant action of flavonoid glycosides. Eur J Pharmacol 2006,539(3),168-176

3. Pinheiro F.P.; Justino G.C.; Phytochemicals - A Global Perspective of Their Role in Nutrition and Health ,33-56

4. McNaught A.D.; Wilkinson A.; IUPAC, Compendium of Chemical Terminology, Electronic version (2006) of IUPAC. In: Compendium of Chemical Terminology, 2nded (The “Gold Book”);

5. Middleton E.; Effect of plant flavonoids on immune and inflammatory cell function In: Flavonoids in the living system Adv Exp Med Biol 1998,439,175-182

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3