Affiliation:
1. Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
Abstract
Background:
Ag-TiO2 nanoparticles catalyzed synthesis of 12-aryl-8,9,10,12-
tetrahydrobenzo[a]-xanthen-11-ones have been enhanced via a three-component one-pot reaction
betweenβ-naphthol, several aldehydes and dimedone in H2O at room temperature. Xanthenes are
essential intermediates in chemistry owing to their vast difference in biological activity.
Methods:
This process offered significant advantages containing appropriate cost efficiency, low
amount of the catalyst, application of low-cost available Ag-TiO2 nanoparticles catalyst, purification
of the product by non-chromatographic method, easy process, good atom economy, simple
isolation and reusability of nanocatalyst.
Result:
Ag-TiO2 nanoparticles catalyst shows easy access to Xanthenes with appropriate yields in
short reaction time and purity. This nanoparticles catalyst was recycled and recovered by easy filtration
and was reused up to five times with only an unimportant loss in its catalytic efficacy.
Conclusion:
This method achieves to have a numerous scope relating to the difference in the aldehydes.
Correspondingly, the attractiveness of this research was that H2O was the only by-product.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Computer Science Applications,Drug Discovery,General Medicine
Cited by
1 articles.
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