Affiliation:
1. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China
2. Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China
Abstract
In the body, millions of cells die and proliferate each day to maintain normal function and
cooperation of all tissues, organs, and systems. Thus, programmed cell death, or apoptosis, is critical to
sustain growth, development, and body health. The vital role of B-cell leukemia/lymphoma-2 (BCL-2)
family proteins in apoptosis has been identified. The BCL-2 family includes both pro- and antiapoptotic
proteins, which are structurally and functionally related, containing up to four BCL-2 homology
(BH) motifs (BH1-4). There are also some nutritional factors that regulate apoptosis via the BCL-2
family proteins. In this review, the BCL-2 family proteins and their apoptosis-inducing mechanism
have been discussed, along with the nutrient factors that regulate apoptosis through the BCL-2 family
proteins.
Funder
Beijing Natural Science Foundation
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Cell Biology,Molecular Biology,Biochemistry,General Medicine
Cited by
21 articles.
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