Cationic Antimicrobial Peptides for Tuberculosis: A Mini-Review-Reference-Cited by-同舟云学术

Cationic Antimicrobial Peptides for Tuberculosis: A Mini-Review

Published:2019-09-17 Issue:9 Volume:20 Page:885-892
ISSN:1389-2037
Container-title:Current Protein & Peptide Science
language:en
Short-container-title:CPPS

Author:

Silva Sara¹,Vale Nuno¹

Affiliation:

1. Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal

Abstract

Cationic antimicrobial peptides (CAMPs) can be considered as new potential therapeutic agents for Tuberculosis treatment with a specific amino acid sequence. New studies can be developed in the future to improve the pharmacological properties of CAMPs and also understand possible resistance mechanisms. This review discusses the principal properties of natural and/or synthetic CAMPs, and how these new peptides have a significant specificity for Mycobacterium tuberculosis. Also, we propose some alternative strategies to enhance the therapeutic activity of these CAMPs that include coadministration with nanoparticles and/or classic drugs.

Funder

FEDER

Portuguese Science and Technology Foundation, FCT

Publisher

Bentham Science Publishers Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,General Medicine

Reference36 articles.

1. World Health Organization2016 Global Tuberculosis Report 2016. World Health Organizatio, Geneva, Switzerland. Available at: ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://apps.who.int/iris/bitstream/10665/250441/1/978924156-5394-eng.pdf?ua=1">http://apps.who.int/iris/bitstream/10665/250441/1/978924156-5394-eng.pdf?ua=1

2. Hancock R.E.W.; Lehrer R.; Cationic peptides: A new source of antibiotics. Trends Biotechnol 1998,16(2),82-88

3. Lakshmaiah N.J.; Chen J.Y.; Antimicrobial peptides: Possible anti-infective agents. Peptides 2015,72,88-94

4. Anaya-López J.L.; López-Meza J.E.; Ochoa-Zarzosa A.; Bacterial resistance to cationic antimicrobial peptides. Crit Rev Microbiol 2013,39(2),180-195

5. Jenssen H.; Hamill P.; Hancock R.E.W.; Peptide antimicrobial agents. Clin Microbiol Rev 2006,19(3),491-511

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Hybrid 2D/3D-quantitative structure–activity relationship studies on the bioactivities and molecular mechanism of antibacterial peptides;Amino Acids;2024-02-15

2. Mycobacterium tuberculosis cell-wall and antimicrobial peptides: a mission impossible?;Frontiers in Immunology;2023-05-17