Therapeutic Application of Bavachalcone in Chronic Diseases: A Concise Report on Medicinal Importance and Pharmacological Activities

Abstract

Background: Psoralea corylifolia L. is an important herbal medicine mainly used for the treatment of coronary artery disease, osteoporosis, bacterial infections, vitiligo, and psoriasis. P. corylifolia contains numerous active phytochemicals including bavachalcone. Polyphenolic compounds, including flavonoidal class phytochemicals are secondary plant metabolites found to be present in numerous plant species and reported to have multiple functions to counteract free radicals. Methods: The aim of the present study is to review the medicinal importance and pharmacological activities of bavachalcone. To know the therapeutic benefit of bavachalcone in medicine, here in the present work we have attempted to provide scientific information of bavachalcone. The present paper has been divided into the overview of flavonoids and P. corylifolia, pharmacological activities of bavachalcone, and analytical aspects of bavachalcone. Detailed pharmacological activities of bavachalcones have been discussed in the present paper. Further Bioanalytical aspects have been also discussed for development of analytical techniques for separation, isolation, and identification of bavachalcone. In the present work, numerous scientific databases such as PubMed, Science Direct, Scopus, Google Scholar, and Google have been searched. Results: Scientific data analysis revealed that bavachalcone is an important phytochemicals, found to be present in P. corylifolia. Scientific data analysis revealed the biological importance and therapeutic benefit of bavachalcone in medicine. Pharmacological data analysis revealed their effectiveness against cancer, oxidative stress, Alzheimer's disease, angiogenesis, tissue repair, osteoclastogenesis and various enzymes. Further pharmacokinetic and analytical data of bavachalcone have been also collected and analyzed in the present work. Conclusion: Scientific data analysis revealed that several molecular mechanisms are responsible for pharmacological activities of bavachalcone.