Protective Role of Eupafolin against Tumor, Inflammation, Melanogenesis, Viral Disease and Renal Injury: Pharmacological and Analytical Aspects through Scientific Data Analysis

Abstract

Background: Plant derived natural products have been always used in medicine for the treatment of human disorders due to their pharmacological activities and safety profile. Plant derived natural products have been used in food, Nutraceuticals and medicine for the better growth and development. Phytoconstituents are pure chemicals derived from various plant material and some of the best examples are tannins, alkaloids, terpenes, terpenoids, coumarins, polysaccharides, glycosides, flavonoids and phenols. Flavonoids are pure phytochemicals present in plants and their derived products and examples are eupafolin, kaempferol, quercetin, apigenin, myricetin, and luteolin. Flavonoids have different pharmacological activities due to their unique chemical structure and ring substitution. MethodS: In the present investigation, various scientific databases, including PubMed, Google, Science Direct and Scopus, have been searched to collect all the needed information of eupafolin. The biological potential and pharmacological activities of eupafolin have been investigated in the present work through literature data analysis of eupafolin through different scientific works. Detailed pharmacological activities of eupafolin have been collected and analyzed in the present work to know their effectiveness in the medicine for the treatment of human disorders. The importance of analytical techniques for the separation, identification and quantification of eupafolin in medicinal plants has been also investigated in the present work through literature data analysis. Results: Analysis of scientific databases revealed that eupafolin is a flavonoid class phytochemical found to be present in Arnica chamissonis, Arnica Montana, Artemisia mongolica, Artemisia princeps, Artemisia scoparia, Chamaemelum nobile, Dimerostemma vestitum, Eupatorium cannabinum, Eupatorium perfoliatum, Gaillardia aristata, Kalanchoe brasiliensis, Kalanchoe pinnata, Korscheltellus gracilis, Lantana montevidensis, Lippia canescens, Lippia dulcis, Phyla nodiflora and Salvia officinalis. Scientific research data analysis revealed the biological importance of eupafolin in medicine due to its anti-tumor, anti-inflammatory, anti-viral and anti-oxidant activity. However its potential on melanogenesis, cardiomyocytes, cerebral ischemia/reperfusion (I/R) injury, glutamate release has been also mentioned in the scientific research work. The study of analytical data revealed the importance of Gas chromatography, GC-MS, HPLC-DAD, HPLC-UV, TLC and UHPLC-MS for qualitative and quantitative analysis of eupafolin in the medicine and other allied health sectors. Conclusion: Eupafolin has a very impressive pharmacological profile and could be used against different types of human disorders.