Affiliation:
1. Department of Pharmacy and Nutrition, Center for Exact Natural and Health Sciences, Federal University of Espirito Santo, Alegre-ES, Brazil
Abstract
Background:
Colorectal cancer is caused by genetic predisposition and lifestyle risk factors
and is associated with altered homeostasis of the intestinal microbiota. Evidence suggests that
chronic infection and inflammation contribute to carcinogenic mutagenesis and promote cancer initiation
and progression. Food components with prebiotic properties, such as fructooligosaccharides
(FOS), promote intestinal integrity and health benefits. Yacon (Smallanthus sonchifolius) is an abundant
source of FOS, which are fermented by beneficial bacteria, improving the intestinal environment
affected by colorectal cancer.
Objective:
In the current review, the aim was to discuss colorectal cancer and its inflammatory process
of development. Also, some general aspects concerning yacon roots and its prebiotic properties
are described. Finely, the beneficial effects of yacon to reduce intestinal parameters altered due to
colorectal cancer are summarized.
Conclusion:
It was verified that yacon might improve immunological parameters, intestinal barrier,
intestinal microbiota, and inflammation in induced colorectal cancer in animals, especially. Researches
with humans must be further investigated to prove these positive effects.
Funder
CAPES
Fundação de Amparo à Pesquisa e Inovação do Espírito Santo
Publisher
Bentham Science Publishers Ltd.
Subject
Public Health, Environmental and Occupational Health,Nutrition and Dietetics,Food Science
Cited by
5 articles.
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