Affiliation:
1. Laboratory of Neurobiology, Poznan University of Medical Sciences, Poznan, Poland
2. Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland
Abstract
:In an aging society, the number of people suffering from Alzheimer's Disease (AD) is still growing. Currently, intensive research is being carried out on the pathogenesis of AD. The results of these studies indicated that oxidative stress plays an important role in the onset and development of this disease. Moreover, in AD oxidative stress is generated by both genetic and biochemical factors as well as the functioning of the systems responsible for their formation and removal. The genetic factors associated with the regulation of the redox system include TOMM40, APOE, LPR, MAPT, APP, PSEN1 and PSEN2 genes. The most important biochemical parameters related to the formation of oxidative species in AD are p53, Homocysteine (Hcy) and a number of others. The formation of Reactive Oxygen Species (ROS) is also related to the efficiency of the DNA repair system, the effectiveness of the apoptosis, autophagy and mitophagy processes as well as the antioxidant potential. However, these factors are responsible for the development of many disorders, often with similar clinical symptoms, especially in the early stages of the disease. The discovery of markers of the early diagnosis of AD may contribute to the introduction of pharmacotherapy and slow down the progression of this disease.
Funder
Poznan University of Medical Sciences
Publisher
Bentham Science Publishers Ltd.
Subject
Clinical Neurology,Neurology
Reference196 articles.
1. Prince M; Wimo A; Guerchet M; Ali G-C; Wu Y-T; Prina M; World Alzheimer Report 2015 The Global Impact of Dementia: An analysis of prevalence, incidence, cost and trends updates.Alzheimer’s Disease International (ADI) 87 2015
2. Prince M.; Comas-Herrera A.; Knapp M.; Guerchet M.; Karagiannidou M.; World Alzheimer Report 2016 Improving: Healthcare for people living with dementia Coverage, Quality and costs now and in the future Alzheimer’s Disease International 2016,1-140
3. Dubois B.; Hampel H.; Feldman H.H.; Scheltens P.; Aisen P.; Andrieu S.; Bakardjian H.; Benali H.; Bertram L.; Blennow K.; Broich K.; Cavedo E.; Crutch S.; Dartigues J.F.; Duyckaerts C.; Epelbaum S.; Frisoni G.B.; Gauthier S.; Genthon R.; Gouw A.A.; Habert M.O.; Holtzman D.M.; Kivipelto M.; Lista S.; Molinuevo J.L.; O’Bryant S.E.; Rabinovici G.D.; Rowe C.; Salloway S.; Schneider L.S.; Sperling R.; Teichmann M.; Carrillo M.C.; Cummings J.; Jack C.R.; Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer’s Association on “The Preclinical State of AD”; July 23, 2015; Washington DC, USA.Preclinical Alzheimer’s disease: Definition, natural history, and diagnostic criteria. Alzheimers Dement 2016,12(3),292-323
4. Holle R.; Grässel E.; Ruckdäschel S.; Wunder S.; Mehlig H.; Marx P.; Pirk O.; Butzlaff M.; Kunz S.; Lauterberg J.; Dementia care initiative in primary practice: study protocol of a cluster randomized trial on dementia management in a general practice setting. BMC Health Serv Res 2009,9(1),91
5. Jóźwiak A.; Otępienie u osób w wieku starszym - Dementia in the elderly. Geriatria [In Polish].2008,2,237-246
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