Rebalancing the Oral Microbiota as an Efficient Tool in Endocrine, Metabolic and Immune Disorders

Author:

Isacco Ciro Gargiulo1ORCID,Ballini Andrea2ORCID,De Vito Danila3ORCID,Nguyen Kieu Cao Diem4ORCID,Cantore Stefania1ORCID,Bottalico Lucrezia5ORCID,Quagliuolo Lucio2ORCID,Boccellino Mariarosaria2ORCID,Di Domenico Marina2ORCID,Santacroce Luigi6ORCID,Arrigoni Roberto7ORCID,Dipalma Gianna1ORCID,Inchingolo Francesco1ORCID

Affiliation:

1. Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy

2. Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy

3. Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro", 70121 Bari, Italy

4. Human Stem Cell Research Center-HSC, Ho Chi Minh City, Vietnam

5. PolyPheno S.r.l. Academic Spin Off, University of Bari "Aldo Moro", 74123 Taranto, Italy

6. Jonian Department, University of Bari "Aldo Moro", 70121 Bari, Italy

7. CNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), 70125 Bari, Italy

Abstract

The current treatment and prevention procedures of oral disorders follow a very targeted approach considering mouth and its structures as a system that is completely independent, than the rest of the body. The main therapeutic approach is to keep the levels of oral bacteria and hygiene in an acceptable range compatible with oral-mouth health, completely separated from systemic microbial homeostasis (eubiosis vs dysbiosis). This can negatively impact the diagnosis of a more complex systemic disease and its progression. Dysbiosis occurs as a consequence of imbalance in oral and gut microbiota which leads to cardiovascular diseases, diabetes mellitus, rheumatoid arthritis, and Alzheimer’s disease, as reported in current literature. Likewise, there is a need to highlight and develop a novel philosophical approach in the treatments for oral diseases that will necessarily involve nonconventional approaches.

Publisher

Bentham Science Publishers Ltd.

Subject

Immunology and Allergy,Endocrinology, Diabetes and Metabolism

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