Affiliation:
1. Department of Basic Medical Sciences, Neuroscience and Sensory Organs, School of Medicine, University of Bari, Bari, Italy
Abstract
Background:
T cell tolerance both at thymic and peripheral levels is a mechanism of protection
finalized to eradicate autoreactive T cell clones and/or to maintain immune homeostasis, especially,
postnatally. Central tolerance occurs in the thymic medulla via a mechanism of negative selection
which leads to the eradication of autoreactive T cell clones.
Mechanisms of Action:
Such a tolerogenic event relies on Fas-mediated apoptosis of autoreactive T
cell clones operated by thymic dendritic cells (DCs), on the one hand. On the other hand, activated
thymic T regulatory (Treg) cells in cooperation with medullary thymic epithelial cells and DCs suppress
autoreactive T cell clones. Peripherally, different types of Treg cells exert the so-called peripheral
tolerance towards autoreactive T cell clones which may have escaped from negative selection
mechanisms. At the same time, peripheral Treg cells activated by tolerogenic DC have antiinflammatory
activities, especially in the intestine towards food and microbial antigens.
Drug Targeting:
Various natural and dietary products, such as vitamins (A, C, D), lactobacilli and
polyphenols will be described for their tolerogenic capacity to attenuate the inflammatory pathway, as
observed in preclinical and clinical studies.
Publisher
Bentham Science Publishers Ltd.
Subject
Immunology and Allergy,Endocrinology, Diabetes and Metabolism
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献