Multi-Target Drugs Against Metabolic Disorders

Author:

Scotti Luciana1,Monteiro Alex France Messias1,de Oliveira Viana Jéssika1,Mendonça Junior Francisco Jaime Bezerra1,Ishiki Hamilton M.2,Tchouboun Ernestine Nkwengoua3,Santos Rodrigo4,Scotti Marcus Tullius1

Affiliation:

1. Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Joao Pessoa, PB, Brazil

2. University of Western Sao Paulo (Unoeste), Presidente Prudente, SP, Brazil

3. Department of Organic Chemistry, Faculty of Science, University of Yaounde IPO Box 812, Yaounde, Cameroon

4. Laboratory of Synthesis and Drug Delivery, Department of Biological Science, State University of Paraiba, Joao Pessoa, PB, Brazil

Abstract

Background: Metabolic disorders are a major cause of illness and death worldwide. Metabolism is the process by which the body makes energy from proteins, carbohydrates, and fats; chemically breaking these down in the digestive system towards sugars and acids which constitute the human body's fuel for immediate use, or to store in body tissues, such as the liver, muscles, and body fat. Objective: The efficiency of treatments for multifactor diseases has not been proved. It is accepted that to manage multifactor diseases, simultaneous modulation of multiple targets is required leading to the development of new strategies for discovery and development of drugs against metabolic disorders. Methods: In silico studies are increasingly being applied by researchers due to reductions in time and costs for new prototype synthesis; obtaining substances that present better therapeutic profiles. Discussion: In the present work, in addition to discussing multi-target drug discovery and the contributions of in silico studies to rational bioactive planning against metabolic disorders such as diabetes and obesity, we review various in silico study contributions to the fight against human metabolic pathologies. Conclusion: In this review, we have presented various studies involved in the treatment of metabolic disorders; attempting to obtain hybrid molecules with pharmacological activity against various targets and expanding biological activity by using different mechanisms of action to treat a single pathology.

Publisher

Bentham Science Publishers Ltd.

Subject

Immunology and Allergy,Endocrinology, Diabetes and Metabolism

Reference238 articles.

1. Congenital anomalies fact sheet updated September 2016. Available at: http://www.who.int/mediacentre/factsheets/fs370/en/ (Accessed December 1, 2017).

2. Metabolic disorders: MedlinePlus. www.nlm.nih.gov. Retrieved 27 July 2015. Available at: www.nlm.nih.govhttps://medlineplus.gov/metabolicdisorders.html (Accessed December 1, 2017).

3. Inherited metabolic disorders overview: overview, clinical features and differential diagnosis, epidemiology and statistics. https://emedicine.medscape.com/article/1183253-overview (Accessed December 1, 2017).

4. Csermely P, Agoston V, Pongor S. The efficiency of multi-target drugs: The network approach might help drug design.

5. Lipton SA. Turning down, but not off.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3