PHARMACOKINETICS OF RARE-EARTH METALS IN THE BODY OF BROILER CHICKENS UNDER THE CONDITIONS OF USING GADOLINIUM AND LANTHANUM ORTHOVANADATE

Abstract

Currently, the search for substances that will help increase the assimilation of nutrients from the diet continues, and the most promising in this regard are nanoparticles of rare earth metals (REM) – orthovanadates of gadolinium (NP GdVO4:Eu3+) and lanthanum (NP LaVO4:Eu3+), synthesized relatively recently, because they provide optimization of the state of pro-oxidant/antioxidant defense systems and oxygen metabolism and showed an adaptogenic effect on the body of white rats under conditions of food stress. The aim of the work was to investigate the pharmacokinetics of rare earth elements in the body of broiler chickens under the conditions of the use of gadolinium and lanthanum orthovanadates. An experiment was conducted on broiler chickens of the "Сobb-500" cross. According to the principle of analogues, 3 experimental and one control group of day-old broiler chickens (n=30) were formed: the chickens of the I experimental group received a solution of NP GdVO4:Eu3+ for 10 days, the II experimental group received a solution NP LaVO4:Eu3+, III experimental group – a solution of NP GdVO4:Eu3+ and NP LaVO4:Eu3+ (on average, chickens received 0.09 (0.13-0.05) mg/kg of NP body weight). After 10 days, NP administration was stopped and the chickens were observed for another 5 days. For the study, samples of muscle stomach, small and large intestine with contents, liver, lungs, brain, feather with skin, thigh muscles, heart, kidneys were taken. It was established that GdVO4:Eu3+ NPs have greater material accumulation, as evidenced by the content of gadolinium in all the examined organs and tissues, and LaVO4:Eu3+ NPs – functional accumulation, since they are less absorbed in the body (lanthanum was determined to a greater extent in the digestive tract). Along with this, the digestive tract can be considered as a kind of depot of nanoparticles of both species, especially lanthanum, since 5 days after the end of administration, both lanthanum and gadolinium are redistributed in the bird's body. Since the main critical period in growing broilers is the first 2 weeks of life, nanoparticles of gadolinium and lanthanum orthovanadates can be used for 5-10 days to overcome stress and increase the adaptation capabilities of the body.