EFFECT OF CHELATES OF MINERAL ELEMENTS ON ADAPTIVE PROCESSES IN THE ORGANISM UNDER OXIDATIVE STRESS

Abstract

A review of literary sources shows the prevalence of the problem of the development of oxidative stress as a side effect of many pathological processes in animals and humans. It is essential to develop ways and means of its prevention and correction since its correction can be a non-specific therapy in developing many pathological processes. The development of oxidative stress caused deviations in redox processes, the permeability of cellular membranes, and their integrity. Overcoming the effects of oxidative stress requires bio-preparations with high bioavailability, which can stimulate the body's natural antioxidant defense system and neutralize the toxic effects of xenobiotics. Reducing the manifestation of oxidative stress is often adapting the body's natural antioxidant protection system to increase the supply or formation of reactive oxygen species and free radical oxidation products. Macro- and microelements are absorbed by the body of animals and humans mainly through the digestive system. To correct deficiencies of certain elements, mineral, and vitamin-mineral supplements used in the diet, and drugs for parenteral administration - under acute deficiency. Chelates of chemical elements are increasingly used in therapeutic practice, as they are characterized by higher bioavailability compared to organic and inorganic salts of the same elements. The use of compounds with higher bioavailability makes it possible to introduce a smaller amount of the drug in terms of metal, which will avoid the irritating effect and improve the organoleptic indicators, preserving or even enhancing the therapeutic effect. Chelates have a lower irritating effect at the same concentrations as in saline solutions. Therefore, the study of the biochemical mechanisms of action of the drug (in particular, in the correction of oxidative stress) is an urgent issue that prompts us to study it to develop a drug with high bioavailability and confirm its effectiveness.