COMPARATIVE ANALYSIS OF THE FEATURES OF THE I NFLAMMATORY RESPONSE IN PATIENTS WITH POST-TRAUMATIC PERICARDITIS AND IN PATIENTS WITH SURGICAL CARDIOVASCULAR PATHOLOGY

Abstract

Summery. Aim. Determination of the Diagnostic and prognostic significance of immunoresistance indicators, the degree of adaptive responses and the regenerative ability of immunophysiological factors that affect the outcome of the disease. Materials and methods. The determination of markers of primary and secondary immunity was applied. 33 victims with post-traumatic pericarditis (Group 1) and 23 patients with surgical cardiovascular Pathology (Group 2) were examined. The features of the occurrence and development of an inflammatory response in victims of both groups were studied. Research results. In the victims of Group 1, a violation of the barrier function of neutrophil phagocytosis was found. In patients of Group 2, a violation of the absorption and digesting ability of phagocytes was detected, which is expressed in a significant increase in the phagocytic number and a decrease in the phagocytosis Completion Index. Conclusions. 1.in patients of the 2nd study group in the pre - and postoperative periods, a violation of the absorption and digesting ability of phagocytes was detected, which is expressed in a significant increase in the phagocytic number and a decrease in the phagocytosis Completion Index. 2.in patients of the same 2 study group, insufficient metabolic function of phagocytic cells was established, which leads to inhibition of oxygen-dependent phagocytosis and impaired lysis of senescent cells. 3. Also, in patients of the same 2 study group, depletion of the oxidative reserve of neutrophils and violation of the redox reserve of neutrophils and a decrease in the expression of differentiating markers of CD T-helper cells and cytotoxic lymphocytes were established. 4. normalization with a moderate increase in VEGF factor in the postoperative period compared to the preoperative period in patients of the 1st study group indicates a positive dynamics of the course of post-traumatic pericarditis. 5. Also, victims of the 1st study group showed a significant increase in neurotrophin NT-3, one of the targets of which is muscle fibers. 6.an increase in β-NGF in patients 1 of the study group with post-traumatic pericarditis indicates an ongoing process of inflammation, stimulation of the sympathetic nervous system and sensory fibers, however, as a decrease in β-NGF in patients with cardiovascular pathology of patients 2 of the study group indicates inhibition of the growth function of individual cell populations.