The use of fluconazole in the treatment of superficial fungal infections- A meta-analysis

Abstract

The study evaluated the efficacy of the once-weekly dose of oral fluconazole 150 mg therapy in dermatophytosis in comparison to placebo or comparator in the adult patient. A systematic literature search was conducted to identify relevant studies published from 2011 until March 2021. Two reviewers independently abstracted data and assessed study quality. Oral fluconazole 150 mg tablet per week is effective in reducing dermatophytosis after 4 weeks (OR 0.14 95% Cl -1.81-1.82). The heterogenicity test shows no substantial changes between the two studies included in the meta-analysis (Chi=2.36, df=1, I=56.68%; P=0.124). Weekly treatment of fluconazole 150 mg by oral route for 4 weeks is effective against dermatophytosis.