Protective effect of Ageratum conyzoides against carbon tetrachloride –induced hepatic damage in rats

Abstract

The present study was conducted toexamine the Hepatoprotective activity against the carbon tetrachloride toxicity in Wister rats. The Petroleum ether, ethyl acetate and methanol extract of was prepared and evaluated for phytochemical screening. The serum level of glutamic oxaloacetate transaminase (SGOT) Glutomicpyruvate transaminase (SGPT) and bilirubin were investigated for the assessment of hepatoprotective activity of ethyl acetate of extract . Additionally, the histological changes in liver were studied. The primary phytochemical investigation of the extract of revealed the presence of Flavonoids, tannins, and carbohydrates. Pretreatment with ethyl acetate extract of showed a significant (P<0.05) decrease in serum SGOT, SGPT and bilirubin when compared to control group rats treated with CCl in dose dependent manner. The outcomes of histology study revealed that there was significant reversal of histological functions of liver. In conclusion, the findings of study validated that the can improve CCl–induced hepatic toxicity.