A high-sensitivity C-reactive protein in assessing severity of asthma: A case control study

Abstract

Asthma is often believed to be a disorder localized to the lungs, current evidence indicates that it may represent a component of systemic airway disease involving the entire respiratory tract. Despite significant improvements in the diagnosis and management of asthma over the past decade, as well as the availability of comprehensive and widely-accepted national and international clinical practice guidelines for the disease.This is prospective and descriptive study patients were derived among patients with asthma presented for follow -up examination in outpatient Department of pulmonary Medicine of Government Hospital. The patients were on maintenance treatment including inhaled corticosteroids and bronchodilators according to the guideline treatment of asthma. In our present study, a total of 65 patients were included out of which 36(55.3%) were males. In our study, most of the patients were 51-70 years i.e., 36 out of 65(55.4%), followed by 31-50. The mean hsCRP in case group patients are 3.62±0.84 and in control group patients 0.83±0.15. Pulmonary lung function test using Spirometer was done in all the patients (case & control). The FEV1 values are compared against hsCRP values. Statistical significance is assessed using Spearmann’s correlation. Case group patients showing highly significant negative correlation of hsCRP with FEV1.The results of this study indicate increased serum hsCRP concentration in asthma compared to controls. Increased serum hs-CRP correlates positively with severity of asthma and thus can be considered as a tool in predicting asthma status.