Affiliation:
1. C
2. Chettinad Dental College and Research Institute, Kelambakkam, Tamil Nadu, India
Abstract
is a gram-negative oral pathobiont that is associated with severe form of periodontitis. This bacterium has various virulence factors which enables the bacterium to colonize the oral cavity, invade and evade the host defences. Leukotoxin and cytolethal distending toxin are the important virulence factors that causes periodontal destruction. Periodontal infections with seems to be refractory to conventional therapy and systemic antibiotics. Hence, leukotoxin represents an ideal anti-virulence target and inhibition of its immunosuppressive activity would eliminate the colonization advantage provided to the bacteria by the toxin. This review provides a comprehensive update of with an emphasis on its virulence factors leukotoxin and cytolethal distending toxin and its role in periodontal destruction and recent developments in the management.
Publisher
IP Innovative Publication Pvt Ltd
Reference55 articles.
1. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016.Lancet 2016;390:1211-59
2. Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: A call for global action
3. Periodontal disease has an impact on patients' quality of life
4. Consensus report. Periodontal diseases: epidemiology and diagnosis.Ann Periodontol 1996;1:16-22
5. Actinobacillus actinomycetemcomitans in human periodontal disease
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献